What is Magnesium L-Threonate?

what is magnesium l-threonate
Dr. Roseann Capanna-Hodge

Dr. Roseann Capanna-Hodge

Magnesium L-threonate is a synthesized form of the essential mineral magnesium. Specifically, it's a form of magnesium combined with threonic acid, a substance resulting from the metabolic breakdown of vitamin C​​. 

This combination creates a magnesium salt that is both water-soluble and effectively absorbed by the body. A significant feature of magnesium L-threonate is its ability to cross the blood-brain barrier, making it particularly beneficial for cognitive abilities and brain disorders​.

What Else is Magnesium L-Threonate Called?

Magnesium L-threonate is also referred to as magnesium threonate​.

How Does Magnesium L-Threonate Work?

Magnesium L-Threonate is a special kind of magnesium that's really good for our brains. Think of our brain as a big puzzle; this magnesium helps fit the pieces together better so we can think clearer and remember things more easily.

It's like a key that unlocks the brain's door, letting the good stuff in while helping our brain cells communicate and stay energized. So, when we take Magnesium L-Threonate, it's like giving our brain a boost to work its best!

Magnesium is a very important element in our diet. Yet, many in the U.S. do not meet the recommended daily allowance for magnesium and are deficient, despite its high importance for brain health​​. 

Magnesium L-threonate stands out for several reasons:

  • It easily crosses the brain's protective filter, the blood-brain barrier, ensuring the brain gets the magnesium it requires​​.
magnesium l threonate
  • Magnesium L-threonate has been shown to increase brain plasticity, which is fundamental for memory and learning​​.
  • There's evidence that this form of magnesium can boost brain-derived neurotrophic factor (BDNF), stimulating the formation of new brain cells​​.
  • Magnesium L-threonate helps boost the mitochondrial membrane potential in neuronal cells.

What is the Dosage for Magnesium L-Threonate?

Neurotastic Recommended use

The recommended dosage varies slightly based on the source, but in general:

  • It is typically less than 144 mg of elemental magnesium, with most supplements coming in a 2g serving size of magnesium L-threonate​.
  • The daily intake is often recommended between 1,500 mg to 2,000 mg​.
  • Some sources indicate that the common dose can range from 500mg to 2000 mg per day, depending on the purpose of supplementation including for attention, anxiety, and cognitive function​​.
  • Research on the effects of Magnesium L-Threonate on the brain at a dosage of 1800 mg in order to improve functioning in those with cognitive impairment (Stanford, 2016). 

How to Take Magnesium L-Threonate?

While specific instructions may vary based on the brand and intended use, it's generally recommended to take magnesium L-threonate with water. It can be taken with or without food. 

Since it has relaxing effects, many take magnesium L-threonate during the evening or when stressed. 

Always read the label and consult a healthcare provider if unsure​.

Why is Magnesium L-Threonate Better Than Other Forms of Magnesium for Brain Health?

Magnesium L-Threonate sets itself apart from other magnesium forms because of its unique ability to address brain health directly. 

Neurotastic Magnesium Supplement

Here's why it's considered superior for cognitive function:

Efficient Brain Transport: 

Unlike most magnesium supplements, Magnesium L-Threonate penetrates the blood-brain barrier and enters brain tissue. This specific attribute makes it crucial for those who aim for enhanced focus, accelerated cognitive function, and amplified brain power​.

Neural Connection Enhancement: 

Researchers have found that L-Threonate is the only magnesium ion that effectively transports magnesium to neuron cells in the brain. This leads to improved synaptic density, meaning a greater number of connections between neurons, which is essential for cognitive functions like memory and attention​​.

Scientific Validation: 

Various animal and human studies have demonstrated its benefits. For instance, L-Threonate has been shown to boost mitochondrial membrane potential in rat hippocampal neurons. This results in a higher amount of magnesium absorbed in cerebrospinal fluids and neurons, which doesn't occur with other common magnesium anions​​.

Addressing Cognitive Decline: 

Memory lapses, like forgetting names or misplacing objects, might seem trivial, but they could indicate deeper cognitive challenges. Magnesium L-Threonate has been recognized to aid both memory and attention, making it invaluable for those experiencing such issues. It even offers potential benefits for conditions like depression and anxiety​.

Protection Against Neurological Damage: 

Alzheimer's disease, for example, results in a loss of brain connections, leading to memory challenges. L-Threonate's mechanism appears to counteract this. It has shown potential in improving memory in rodents with severe memory dysfunction and slowing down hyperactive signaling pathways in the brain, which can lead to neurological damage. It also positively impacts the hippocampus, the brain's memory center​​.

In conclusion, while all forms of magnesium offer health benefits, Magnesium L-Threonate stands out because of its profound impact on brain health and cognitive function. Its unique ability to cross the blood-brain barrier, enhance neuronal connections, and support brain function makes it the preferred choice for those seeking a brain-boosting supplement. 

These benefits make it a valuable resource for parents of children and teens with behavioral and mental health challenges. 

If you are ready to start with natural solutions, magnesium might be your next step because of its positive effects on the brain and body. Magnesium L-Threonate Powder is an easy add on for kids, adults and the whole family. 

Always consult with a healthcare professional before starting any supplementation to ensure its appropriateness for individual needs.


Pouteau, E., Kabir-Ahmadi, M., Noah, L., Mazur, A., Dye, L., Hellhammer, J., Pickering, G., & Dubray, C. (2018). Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PloS one, 13(12), e0208454. https://doi.org/10.1371/journal.pone.0208454

Slutsky, I., Abumaria, N., Wu, L. J., Huang, C., Zhang, L., Li, B., Zhao, X., Govindarajan, A., Zhao, M. G., Zhuo, M., Tonegawa, S., & Liu, G. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165–177. https://doi.org/10.1016/j.neuron.2009.12.026

Sun, Q., Weinger, J. G., Mao, F., & Liu, G. (2016). Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration. Neuropharmacology, 108, 426–439. https://doi.org/10.1016/j.neuropharm.2016.05.006

Stanford University (2016) Magnesium L-Threonate for the Enhancement of Learning and Memory in People With Dementia. Retrieved from https://classic.clinicaltrials.gov/ct2/show/NCT02210286

Wu, S, Jin, T, Ma, B, et al.. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients—A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023; 12: 4343-4351. doi: 10.1002/cam4.4922

Zhang, C., Hu, Q., Li, S., Dai, F., Qian, W., Hewlings, S., Yan, T., & Wang, Y. (2022). A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients, 14(24), 5235. https://doi.org/10.3390/nu14245235

Are you looking for SOLUTIONS for your struggling child or teen? 

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Dr. Roseann is a Children’s Mental Health Expert and Licensed Therapist who has been featured in/on hundreds of media outlets including The Mel Robbins Show, CBS, NBC, PIX11 NYC, Today, FORBES, CNN, The New York Times, The Washington Post, Business Insider, Women’s Day, Healthline, CNET, Parade Magazine and PARENTS. FORBES called her, “A thought leader in children’s mental health.

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She coined the terms, “Re-entry panic syndrome” and “eco-anxiety” and is a frequent contributor to media on mental health. 

Dr. Roseann Capanna-Hodge has three decades of experience in working with children, teens and their families with attention-deficit hyperactivity disorder (ADHD), autism, concussion, dyslexia and learning disability, anxiety, Obsessive Compulsive Disorder (OCD), depression and mood disorder, Lyme Disease, and PANS/PANDAS using science-backed natural mental health solutions such as supplements, magnesium, nutrition, QEEG Brain maps, neurofeedback, PEMF, psychotherapy and other non-medication approaches. 

She is the author of three bestselling books, It’s Gonna Be OK!: Proven Ways to Improve Your Child's Mental Health, The Teletherapy Toolkit, and Brain Under Attack. Dr. Roseann is known for offering a message of hope through science-endorsed methods that promote a calm brain.

Her trademarked BrainBehaviorResetⓇ Program and It’s Gonna be OK!Ⓡ Podcast has been a cornerstone for thousands of parents facing mental health, behavioral or neurodevelopmental challenges.

She is the founder and director of The Global Institute of Children’s Mental Health, Neurotastic™Brain Formulas and Dr. Roseann Capanna-Hodge, LLC. Dr. Roseann is a Board Certified Neurofeedback (BCN) Practitioner, a Board Member of the Northeast Region Biofeedback Society (NRBS), Certified Integrative Mental Health Professional (CIMHP) and an Amen Clinic Certified Brain Health Coach.  She is also a member of The International Lyme Disease and Associated Disease Society (ILADS), The American Psychological Association (APA), Anxiety and Depression Association of America (ADAA) National Association of School Psychologists (NASP), International OCD Foundation (IOCDF).

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