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How Long Does it Take for Magnesium L-Threonate to Work

how long does it take for magnesium l-threonate to work
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Dr. Roseann Capanna-Hodge

Magnesium L-Threonate is rapidly emerging as a powerful ally for parents with children and teens grappling with behavioral and mental health challenges. But how long does it take for this form of magnesium to start showing its effects? Let's delve into the intricacies of Magnesium L-Threonate and its myriad benefits.

So, How Long Does it Take for Magnesium L-Threonate to Work?

Magnesium L-Threonate is a unique form of magnesium designed to boost magnesium levels in the brain. For some, they notice an immediate sensation of calm and for others, it takes days or weeks to notice a reduction of stress levels or improvement in sleep, focus or cognition. 

While the precise time frame for its effects can vary among individuals, there are some general observations:

Clinical Trials: 

In a study involving older adults concerned about memory, concentration, anxiety, and sleep, participants were administered magnesium L-threonate for 12 weeks. At the end of this period, significant improvements were noticed in cognitive areas like working memory, episodic memory, attention, and executive function​ (Mickley et al. 2013). 

General Observations: 

Many individuals report observing changes in their cognitive abilities after approximately three weeks of usage. However, for some, it may take up to six weeks to notice these changes​. 

Optimal Duration: 

For the best results, it is recommended to continue the supplementation for at least 12-16 weeks​.

It's essential to understand that individual results can vary based on factors like age, baseline magnesium levels, and specific cognitive concerns. However, the overarching consensus underscores the potential of magnesium L-threonate in promoting cognitive health.

Research on How Long it Takes for Magnesium L-Threonate to Work

One study investigated the effects of dietary magnesium-L-threonate on conditioned taste aversion in older adults (ages 50 through 70) who expressed concerns related to memory, concentration, anxiety, and sleep. 

Participants were assessed on cognitive abilities, including working memory, episodic memory, attention, and executive function. 

After 12 weeks of magnesium l-threonate supplementation, the results demonstrated a significant increase in magnesium levels in brain cells.

Furthermore, all participants showcased notable improvement across all cognitive areas assessed. Additionally, the biological brain age of the participants was found to be reduced significantly, suggesting that their brains functioned as if they were approximately 9.4 years younger by the end of the study​ (Mickley et al. 2013).

Research on How Long it Takes for Magnesium L-Threonate to Work


Factors That Influence How Long Does it Take for Magnesium L-Threonate to Work

The onset of benefits from Magnesium L-Threonate can vary based on several factors:

Individual Biochemistry: 

Every child's body is unique, and how quickly they absorb and utilize magnesium can differ. Factors such as genetic variants, gut health, stress levels, and so on can affect absorption. 

Current Magnesium Levels: 

Children with more severe magnesium deficiencies might notice improvements sooner once they begin supplementation.

Diet and Lifestyle:

A diet rich in magnesium-rich foods or one that's supplemented with Magnesium L-Threonate can influence how soon its positive effects are observed.

Medication Usage:

Certain medications can deplete magnesium, which increases the need for magnesium. 

Stress Levels and Illness:

Conditions like stress and illness can deplete magnesium, which increases the need for magnesium.

What Physical and Mental Wellness Changes Should You See With Magnesium L-Threonate

Magnesium is often described as a silent superhero, tirelessly working behind the scenes to maintain your child's brain health​.  When magnesium levels decline too drastically, it can disrupt this equilibrium, leading to issues like ADHD, depression, and anxiety in children​.

By ensuring your child gets enough magnesium, you're effectively giving their brain the tools it requires to function optimally, bolstering their mental health and well-being​.

How to Use Magnesium L-Threonate

Magnesium L-Threonate can be introduced into your child's regimen either through magnesium-rich foods or as a supplement. By prioritizing their magnesium intake, you're proactively supporting their overall health and well-being​​.

Neurotastic Magnesium Supplement

Why Does the Brain and Body Need Magnesium?

Think of magnesium as your child's body's best friend. It bolsters their muscles and nerves, aids in controlling blood sugar and blood pressure, assists in building proteins, bones, and DNA, and is a significant proponent of your child's brain health​.

Magnesium plays a pivotal role in your child's brain communication. It calms their nervous system by silencing those intense signals in the brain that can make them feel overly agitated or anxious​.

Magnesium For Health

Magnesium L-Threonate is more than just a supplement; it's a beacon of hope for parents with children facing mental and behavioral challenges. Whether it's bolstering cognitive function, enhancing levels of magnesium in the brain, or supporting healthy mental growth, Magnesium L-Threonate has solidified its position as an essential ally. 

Although the timeline for its effects can vary, the consensus is clear: maintaining optimal magnesium levels in the brain can be transformative for children and teens.

If you are ready to start with natural solutions, magnesium might just be the place to start. Magnesium L-Threonate Powder is a highly bioavailable form that lets one easily control the dosage. 


Mickley, G. A., Hoxha, N., Luchsinger, J. L., Rogers, M. M., & Wiles, N. R. (2013). Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. Pharmacology, biochemistry, and behavior, 106, 16–26.

Slutsky, I., Abumaria, N., Wu, L. J., Huang, C., Zhang, L., Li, B., Zhao, X., Govindarajan, A., Zhao, M. G., Zhuo, M., Tonegawa, S., & Liu, G. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165–177.

Zhang, C., Hu, Q., Li, S., Dai, F., Qian, W., Hewlings, S., Yan, T., & Wang, Y. (2022). A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients, 14(24), 5235.

Are you looking for SOLUTIONS for your struggling child or teen? 

Dr. Roseann and her team are all about science-backed solutions, so you are in the right place! 

Grab your complimentary copy of
147 Therapist-Endorsed Self-Regulation Strategies for Children: A Practical Guide for Parents

You can get her books for parents and professionals, including: It’s Gonna Be OK™: Proven Ways to Improve Your Child’s Mental Health, Teletherapy Toolkit™ and Brain Under Attack: A Resource For Parents and Caregivers of Children With PANS, PANDAS, and Autoimmune Encephalopathy.

If you are a business or organization that needs proactive guidance to support employee mental health or an organization looking for a brand representative, check out Dr. Roseann’s professional speaking page to see how we can work together.

Dr. Roseann is a Children’s Mental Health Expert and Licensed Therapist who has been featured in/on hundreds of media outlets including The Mel Robbins Show, CBS, NBC, PIX11 NYC, Today, FORBES, CNN, The New York Times, The Washington Post, Business Insider, Women’s Day, Healthline, CNET, Parade Magazine and PARENTS. FORBES called her, “A thought leader in children’s mental health.

Dr. Roseann - Brain Behavior Reset Parent Toolkit

She coined the terms, “Re-entry panic syndrome” and “eco-anxiety” and is a frequent contributor to media on mental health.

Dr. Roseann Capanna-Hodge has three decades of experience in working with children, teens and their families with attention-deficit hyperactivity disorder (ADHD), autism, concussion, dyslexia and learning disability, anxiety, Obsessive Compulsive Disorder (OCD), depression and mood disorder, Lyme Disease, and PANS/PANDAS using science-backed natural mental health solutions such as supplements, magnesium, nutrition, QEEG Brain maps, neurofeedback, PEMF, psychotherapy and other non-medication approaches.

She is the author of three bestselling books, It’s Gonna Be OK!: Proven Ways to Improve Your Child's Mental Health, The Teletherapy Toolkit, and Brain Under Attack. Dr. Roseann is known for offering a message of hope through science-endorsed methods that promote a calm brain.

Her trademarked BrainBehaviorResetⓇ Program and It’s Gonna be OK!Ⓡ Podcast has been a cornerstone for thousands of parents facing mental health, behavioral or neurodevelopmental challenges.

She is the founder and director of The Global Institute of Children’s Mental Health, Neurotastic™Brain Formulas and Dr. Roseann Capanna-Hodge, LLC. Dr. Roseann is a Board Certified Neurofeedback (BCN) Practitioner, a Board Member of the Northeast Region Biofeedback Society (NRBS), Certified Integrative Mental Health Professional (CIMHP) and an Amen Clinic Certified Brain Health Coach.  She is also a member of The International Lyme Disease and Associated Disease Society (ILADS), The American Psychological Association (APA), Anxiety and Depression Association of America (ADAA) National Association of School Psychologists (NASP), International OCD Foundation (IOCDF).

© Roseann-Capanna-Hodge, LLC 2023

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