Is it ADHD or something else?

119: MTHFR and Mental Health

When we identify these MTHFR-related risks, we allow for early intervention and preventive measures. That’s why it’s necessary for us to talk about MTHFR and its impacts on mental health.

MTHFR mutations are deemed to be relatively common but the strong link between MTHFR mutations and mental health has gained attention in recent years. This connection is often associated with an increased risk of various mental health conditions, such as depression, anxiety, bipolar disorder, and schizophrenia.

People with MTHFR gene mutations may be at an increased risk of other mental health issues which highlights the importance of personalized treatment and support. When we identify these MTHFR-related risks, we allow for early intervention and preventive measures. That's why it’s necessary for us to talk about MTHFR and its impacts on mental health.

What is MTHFR?

I frequently get asked about MTHFR and its effects on mental health. MTHFR is a genetic mutation that significantly affects an individual’s mental health. Although it is still important to note that MTHFR is just one factor that can contribute to mental health problems. Other factors, such as genetics, environment, and lifestyle, also play a role.

There are several different mutations for MTHFR, but the most common ones are C677T and A1298C. C677T, which reduces the MTHFR activity, is more common in European descent whereas the A1298C is more common in Asian populations. People with these mutations have a decreased ability to convert folate into methyl folate which is why the MTHFR gene variants can influence physical and mental health misuses linked to folate metabolism, including mood disorders and cognitive impairments.

Common difficulties associated with MTHFR.

There are many toxins surrounding us in our daily environment which is why it is important for us to detoxify. These toxins can build up over time and cause various health problems such as neurological problems, mental health problems, and other health problems.

Without nutrients from B6 and B12, your nervous system, particularly neurotransmitters, cannot work properly. With respect to the long-term effects of MTHFR, it can be associated with cardiac problems, stroke, autoimmune conditions, ADHD, anxiety, OCD, depression and others. In fact, I have never met anyone with bipolar disorder that didn’t have MTHFR and so this establishes a strong link between MTHFR and mental health.

MTHFR genetic mutation also impacts how psychiatric medication works and we've known this since 2000. That is why the Journal of American Psychiatry recommends that all psychiatrists do genetic testing prior to giving medication for better and more effective results.

What do you do if you need a solution?

I always emphasize the need to have a qualified, functional and reputable mental health professional. You can also ask your psychiatrist to run genetic testing which is common nowadays. It's really important to get proper support and find help from somebody who fully understands.

Mental health care often involves a holistic approach which is why seeking help from mental health professionals who are well-trained and experienced in their field is crucial for effective diagnosis, treatment, and support for individuals with mental health concerns.

Monitoring nutrient deficiencies could be a game changer in your child's mental health insofar as nutrient deficiencies can lead to a variety of health problems, including mental health problems such as depression, anxiety, and ADHD. That’s why genetic testing is becoming more common nowadays, and it can be a helpful tool for understanding your mental health.

For more information, you can check this blog post: MTHFR and ADHD OCD Anxiety and Depression

Is your child struggling with attention and executive functioning skills? Learn how to get your kid to listen and finish tasks in 30 days without the constant nagging and fighting. Get the Dr. Roseann's Parenting Toolkit for only $47 today!

➡️ Join our FREE Natural Parenting Community to receive science-backed resources for your child and family. Join here.

➡️ Get help from Dr. Roseann and her team. Apply here. 

➡️ “Is it ADHD or something else?” Take the quiz. 

Scroll to Top
7 day challenge

Counter your overwhelm and reset your nervous system in 7 days

7 Days to
Self Regulation

Challenge starts on April 22!

Download Your Copy

147 Therapist-Endorsed

Self-Regulation Strategies

for Children

A Practical Guide For Parents

147 therapist endorsed self-regulation strategies for children a practical guide for parents
Skip to content