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Best Supplements for Neuroinflammation: A Parent’s Handbook

Best Supplements for Neuroinflammation
Picture of Dr. Roseann Capanna-Hodge

Dr. Roseann Capanna-Hodge

If your listening to my podcast, then you are hearing more and more about how neuroinflammation is impacting mental health. So what really is neuroinflammation and just how can it impact your child’s brain?

Neuroinflammation is the brain's immune system response to injury, infection, toxins, pesticides, or disease. Today, brain inflammation due to our highly toxic laden environment is almost the norm amongst by patients 

For parents dealing with children who have issues with neuroinflammation, understanding how to combat it is crucial. The good news is there are natural supplements for inflammation that can help reduce and manage these symptoms.

Neuroinflammation and it How it Affects the Brain

So how does brain inflammation affect the brain? Excitotoxicity, oxidative stress, and neuroinflammation are interconnected factors implicated in various neurological disorders. They form a “neurotoxic triad” that perpetuates each other's effects. 

There are ways to combat neuroinflammation. 

One study reintroduces the concept of the neurotoxic triad and explores how certain dietary micronutrients can mitigate oxidative stress, excitotoxicity, and neuroinflammation. Future dietary interventions for neurological disorders may simultaneously target all three aspects of the neurotoxic triad (Holton, 2021).

Micronutrients, including vitamins and minerals, are essential for brain health. They play a significant role in reducing inflammation by modulating the immune response and protecting against oxidative stress.

Essential Micronutrients and Their Benefits

There's a lot of interest in special foods or supplements called neuronutraceuticals that might help our brains as they are gaining attention for their potential to preserve brain health (Shakta Mani Satyam & Laxminarayana Kurady Bairy, 2022).

Neuronutraceuticals are special foods or dietary supplements that contain nutrients believed to support brain health and function. They're designed to provide specific compounds that may promote cognitive function, protect against neurodegeneration, and support overall brain health. These compounds can include vitamins, minerals, antioxidants, and other bioactive substances that are thought to benefit the brain. 

  • Vitamin C: Known for its antioxidant properties, Vitamin C helps neutralize free radicals that cause inflammation. It's one of the best vitamins for pain and inflammation.
  • Vitamin E: This vitamin reduces oxidative stress and has anti-inflammatory effects, making it an excellent vitamin for inflammation.
  • Riboflavin (Vitamin B2): It helps produce energy and reduces neuroinflammation by lowering oxidative stress.
  • Vitamin D: It modulates the immune system and reduces inflammation. Vitamin D inflammation supplements are essential for brain health.

Powerhouse Supplements for Neuroinflammation


Powerhouse Supplements for Neuroinflammation

A range of supplements have shown promising potential in combating neuroinflammation, a significant factor in various neurological disorders. These powerhouse supplements are packed with nutrients and bioactive compounds for improved brain function.

1. Curcumin

Curcumin, the active compound in turmeric, is renowned for its potent anti-inflammatory properties. It inhibits inflammatory pathways and reduces levels of cytokines, particularly the interleukin-1 family, which are involved in the inflammatory response. Top-rated turmeric supplements can significantly help reduce neuroinflammation and be more effective than some pharmaceuticals.

2. Bacopa Monnieri

Bacopa Monnieri is an herb traditionally used in Ayurvedic medicine. It's known for improving cognitive function and reducing inflammation in the brain. It reduces the production of pro-inflammatory cytokines like interleukin and promotes antioxidant activity.

3. Probiotics

A healthy gut microbiome is crucial for brain health. Probiotics help maintain this balance and reduce inflammation. Supplements for gut health and inflammation are essential as they reduce systemic inflammation that can affect the brain. Probiotics can act as natural alternatives to prednisone for inflammation by regulating immune responses.

4. Essential Fatty Acids (Fish Oil)

Fish oil is rich in Omega-3 fatty acids, which are known to reduce inflammation and improve brain function. Fish fighter products like fish oil supplements are among the best supplements for anti-inflammation. They help lower levels of inflammatory markers and support brain health, making them crucial anti-inflammatory supplements for joints and the brain.

5. Cocoa Flavanols 

Cocoa flavanols, found in dark chocolate, have been shown to improve brain function and reduce inflammation. They enhance blood flow to the brain and reduce inflammatory cytokines, making them an effective anti-inflammatory supplement.

6. Glutathione

Glutathione is a powerful antioxidant that helps reduce oxidative stress and inflammation. It supports the immune system and detoxifies the brain, making it a critical natural inflammatory supplement.

7. Magnesium

Our Magnesium has Magnesium L-Threonate and L-Glycinate

Magnesium, an essential mineral, plays a vital role in brain health, and its deficiency has been linked to increased neuroinflammation, which is associated with various neurological disorders. Research suggests that magnesium acts as a natural anti-inflammatory agent in the brain by modulating immune responses and reducing the production of pro-inflammatory molecules.

How to Incorporate These Supplements to Reduce Inflammation

Always check with a healthcare professional before starting any new supplement, especially for children. Always incorporate foods rich in these micronutrients and supplements, such as fatty fish, citrus fruits, and dark leafy greens.

Regular intake of these supplements can help maintain their anti-inflammatory effects. Focus on a balanced diet rich in anti-inflammatory foods. Furthermore, ensure adequate sleep and stress management for your child. Regular physical activity can also help reduce inflammation.

Neuroinflammation can be challenging, but inflammation can be managed effectively with the right approach and natural supplements. From fish oil to curcumin, various supplements help with inflammation. These natural solutions reduce inflammation and support overall brain health, allowing your child to lead healthier lives.

Use a powerful magnesium supplement that supports a calm brain and mental wellness. Get the Neurotastic Multi-MagTM Brain Formula today.


Holton, K. F. (2021). Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress, and Neuroinflammation: A Perspective. Frontiers in Neuroscience, 15.

Shakta Mani Satyam, & Laxminarayana Kurady Bairy. (2022). Neuronutraceuticals Combating Neuroinflammaging: Molecular Insights and Translational Challenges—A Systematic Review. Nutrients, 14(15), 3029–3029.

What is the most effective natural anti-inflammatory treatment?

The most effective natural anti-inflammatory treatment varies depending on individual needs and conditions. However, lifestyle changes, such as maintaining a healthy diet rich in fruits, vegetables, omega-3 fatty acids, and regular exercise, can help reduce inflammation.

What is the best natural anti-inflammatory supplement?

Omega-3 fatty acids, found in fish oil supplements, are often considered among the best natural anti-inflammatory supplements due to their potent anti-inflammatory properties.

How can I get rid of inflammation?

To reduce inflammation, focus on adopting an anti-inflammatory diet rich in fruits, vegetables, whole grains, healthy fats, and lean proteins while minimizing processed foods, sugary drinks, and excessive alcohol intake. Regular exercise, stress management techniques, and adequate sleep combat inflammation.

What vitamin helps with inflammation the most?

Vitamin D is known to help with inflammation by modulating the immune system and reducing the production of pro-inflammatory molecules.

How does Vitamin C help with inflammation?

Vitamin C acts as an antioxidant and anti-inflammatory agent by scavenging free radicals and reducing oxidative stress, which can contribute to inflammation in the body.

What is better than fish oil for inflammation?

Krill oil, which contains omega-3 fatty acids in a different form than fish oil, may be considered better than fish oil for some individuals due to its potentially higher bioavailability and additional antioxidant properties.

What vitamin helps with inflammatory cells in the brain?

Vitamin D is known to help regulate inflammatory responses in the brain, potentially reducing inflammatory cells' activity.

Is Vitamin C an anti-inflammatory treatment?

Vitamin C possesses some anti-inflammatory properties due to its antioxidant effects, but it is not typically considered a primary anti-inflammatory treatment.

Do antioxidants reduce inflammation?

Yes, antioxidants, including vitamins C and E, can help reduce inflammation by neutralizing harmful free radicals in the body. A diet rich in antioxidant-rich foods such as fruits, vegetables, nuts, and seeds can help combat inflammation.

How do you fight inflammation?

To fight inflammation, focus on adopting a healthy lifestyle that includes a balanced diet, regular physical activity, stress management techniques like mindfulness or meditation, adequate sleep, and avoiding habits like smoking and excessive alcohol consumption.

Dr. Roseann is a mental health expert in Natural Solutions who is frequently in the media:


Always remember… “Calm Brain, Happy Family™”

Disclaimer: This article is not intended to give health advice and it is recommended to consult with a physician before beginning any new wellness regime. *The effectiveness of diagnosis and treatment vary by patient and condition. Dr. Roseann Capanna-Hodge, LLC does not guarantee certain results.

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Dr. Roseann is a Children’s Mental Health Expert and Licensed Therapist who has been featured in/on hundreds of media outlets including The Mel Robbins Show, CBS, NBC, PIX11 NYC, Today, FORBES, CNN, The New York Times, The Washington Post, Business Insider, Women’s Day, Healthline, CNET, Parade Magazine and PARENTS. FORBES called her, “A thought leader in children’s mental health.

Dr. Roseann - Brain Behavior Reset Parent Toolkit

She coined the terms, “Re-entry panic syndrome” and “eco-anxiety” and is a frequent contributor to media on mental health. 

Dr. Roseann Capanna-Hodge has three decades of experience in working with children, teens and their families with attention-deficit hyperactivity disorder (ADHD), autism, concussion, dyslexia and learning disability, anxiety, Obsessive Compulsive Disorder (OCD), depression and mood disorder, Lyme Disease, and PANS/PANDAS using science-backed natural mental health solutions such as supplements, magnesium, nutrition, QEEG Brain maps, neurofeedback, PEMF, psychotherapy and other non-medication approaches. 

She is the author of three bestselling books, It’s Gonna Be OK!: Proven Ways to Improve Your Child's Mental Health, The Teletherapy Toolkit, and Brain Under Attack. Dr. Roseann is known for offering a message of hope through science-endorsed methods that promote a calm brain. 

Her trademarked BrainBehaviorResetⓇ Program and It’s Gonna be OK!Ⓡ Podcast has been a cornerstone for thousands of parents facing mental health, behavioral or neurodevelopmental challenges.

She is the founder and director of The Global Institute of Children’s Mental Health, Neurotastic™Brain Formulas and Dr. Roseann Capanna-Hodge, LLC. Dr. Roseann is a Board Certified Neurofeedback (BCN) Practitioner, a Board Member of the Northeast Region Biofeedback Society (NRBS), Certified Integrative Mental Health Professional (CIMHP) and an Amen Clinic Certified Brain Health Coach.  She is also a member of The International Lyme Disease and Associated Disease Society (ILADS), The American Psychological Association (APA), Anxiety and Depression Association of America (ADAA) National Association of School Psychologists (NASP), International OCD Foundation (IOCDF).

© Roseann-Capanna-Hodge, LLC 2024

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